Posted 02.12.2020 | by AMRA
Approximately half of older adults diagnosed with mild cognitive impairment (MCI) eventually progress to develop Alzheimer’s Disease. A diagnosis of MCI may provide a window of opportunity to slow, halt, or reverse further cognitive decline, and researchers are interested in novel interventions to help maintain cognitive functioning.
Mindfulness-based interventions may offer a means to potentially preserve cognitive function by lowering stress and inflammation and promoting neuroplasticity. Inflammation is associated with cognitive impairment, the arterial changes associated with vascular dementia, and the inter-neuronal plaque formation associated with Alzheimer’s disease.
Ng et al. [Translational Psychiatry] conducted a randomized controlled pilot study investigating the effects of a mindfulness-based program on biomarkers of stress, inflammation, and neuroplasticity in older adults with MCI.
The researchers randomly assigned 55 older adults (average age = 71 years; 75% Female; 98% Singaporean Chinese) with MCI to Mindful Awareness Practice (MAP) or a health education control group. For the first three months, MAP and control participants attended 12, weekly, 1-hour sessions. For the subsequent 6-months, they attended once monthly 1 hour booster sessions.
MAP was modelled after Mindfulness-Based Elder Care, an adaptation of Mindfulness-Based Stress Reduction for older adults with impairments in attention-span and difficulty in following instructions. The mindfulness program included mindful breathing, sensory mindfulness, body scanning, and mindful movement components.
The health education control covered topics such as sleep, diet, exercise, grief, stress, social support, and the management of common chronic diseases associated with aging.
Participants provided blood and saliva sample at baseline, 3 months, and 9 months. Researchers obtained blood biomarkers of inflammation (C-reactive protein, IL-6 and IL-1β), saliva biomarkers of stress (cortisol and DHEA-S), and a blood biomarker of neuroplasticity (BDNF, a protein […]