Posted 05.18.2017 | by AMRA
Being diagnosed and treated for cancer can be highly stressful, and prolonged stress often alters the body’s normal stress response. For example, the amount of cortisol (a stress hormone) secreted by the adrenal gland typically varies over the course of the day, peaking upon morning awakening and gradually diminishing throughout the day. Prolonged stress blunts this biological response so that the difference between morning and afternoon cortisol levels is much smaller.
Cancer survivors often show this kind of blunted cortisol response—reduced daily variation and reduced reactivity to stress. This blunting of stress reactivity is associated with greater disease progression and shorter survival times for many types of cancers. It’s possible that somehow preventing this blunting may improve patient outcomes. Prior research shows that mindfulness-based interventions (MBIs) can limit cortisol blunting across the day in breast and prostate cancer patients.
Black et al. [Cancer] conducted a randomized, controlled test of whether a brief mindfulness activity could reduce the blunting of acute cortisol reactivity in colorectal cancer patients undergoing chemotherapy infusion.
The researchers randomly assigned 57 adults with colorectal cancer (average age = 54 years; 51% Male; 66% non-Hispanic, 33% Hispanic/Latino) who were undergoing chemotherapy infusion to one of three conditions: 1) a standard chemotherapy control group, 2) a chemotherapy + cancer education attention control group, and 3) a mindfulness meditation + cancer education group.
Saliva samples (to assess cortisol levels) were drawn four times during the hour-long chemotherapy infusion: at the start of infusion and at three 20-minute intervals thereafter. The patients also completed self-report measures of stress, anxiety, depression, and fatigue during the past week, as well as general levels of mindfulness (using a short form […]