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  • 8 Aug 2022 2:15 PM | Anonymous member (Administrator)

    Our body’s adaptive response to a stressor occurs in temporal phases and is the outcome of complex interactions between the sympathetic and parasympathetic nervous systems and the endocrine system. This phased time scale is the outcome of feedback loops between the systems and the time it takes for stress hormones to both enter the blood stream and subsequently be deactivated. Many studies ignore this complexity by measuring stress at a single timepoint or with only a sole biomarker. 

    Gamaiunova, et al. [Biological Psychology] tested the effects of two different mindfulness-based interventions on multiple biological measures of stress across different temporal phases of the stress response. A better understanding of the temporal dynamics of these measures might help us better understand discrepancies between studies that show different results.

    The researchers randomly assigned 99 healthy Swiss adult volunteers to Mindfulness-Based Stress Reduction (MBSR), Buddhist-enhanced Mindfulness-Based Stress Reduction (MBSR-B), or a waitlist control. Attrition was high, and data from only 65 participants (average age = 29 years; 65% female) were analyzed. MBSR was taught in 8 weekly 2.5-hour sessions with a 7th week retreat day and 55 minutes a day of homework. MBSR-B was similarly structured but included additional material on the Buddhist themes of impermanence, ethics, lovingkindness, compassion, non-self, and craving.

    Following the study interventions, participants completed a social stress task in a laboratory setting. After being hooked up to an electrocardiograph (EKG), participants rested for ten minutes. Participants were then given 15 minutes to prepare a talk as part of a stress task. During the stress task, participants gave 5-minute speeches and engaged in 5 minutes of mental arithmetic while being recorded on camera and observed by two research assistants wearing white lab coats. The participants then remained in the lab for a 30-minute recovery period. EKGs were recorded from the start of the rest period through the recovery period. 

    Saliva samples of cortisol (a stress hormone) and α-amylase (a surrogate for serum epinephrine and norepinephrine) were drawn during the rest, anticipation, task, and recovery periods. EKGs were analyzed for heart rate variability and the duration of the pre-ejection period. Heart rate variability increases due to parasympathetic activity, and the pre-ejection period shortens due to sympathetic activity. Participants were also asked to rate their positive and negative affect during rest, anticipation, task, and recovery.

    The results showed both MBSR groups had significantly lower cortisol levels under the curve during the anticipatory period than controls (d=0.78-0.82). They also showed significantly lower relative percent decreases in pre-ejection period duration than controls during the anticipatory (d=0.71-0.82) and task (d=0.70-0.87) periods, but not during the recovery period. Both MBSR groups showed a significantly lesser relative percent decrease in heart rate variability during the anticipatory (d = 0.72-0.88) and task (d = 0.88-1.05) periods than controls, but only the MBSR-B group showed a significant effect (d = 1.10) during the recovery period when compared to the control group. 

    The MBSR-B group reported smaller increases in negative affect than controls during the anticipatory phase (d=.97) while both treatment groups reported smaller increases in negative affect during the task phase (d=0.95-0.88). The treatment groups also reported smaller declines in positive affect than controls during the task phase (d =0.95-0.91). No between-group differences were noted for α-amylase levels.

    The study shows MBSR and MBSR-B both reduce subjective and biological components of the laboratory-induced stress response, but these effects vary depending on the measure used and the phase of the stress response during which they were measured. The study was limited in its power to detect significant differences due to its relatively high attrition rate.


    Gamaiunova, L., Kreibig, S. D., Dan-Glauser, E., Pellerin, N., Brandt, P.-Y., & Kliegel, M. (2022). Effects of Two Mindfulness Based Interventions on the Distinct Phases of the Stress Response Across Different Physiological Systems. Biological Psychology.

    Link to study

  • 3 Aug 2022 11:51 AM | Anonymous member (Administrator)

    Ulcerative colitis is a debilitating chronic inflammatory bowel disease with symptoms that include diarrhea, abdominal pain, fecal incontinence, fever, and fatigue. The disease is characterized by acute symptomatic flares interspersed with periods of asymptomatic remission. Flares can be triggered by stress, and mindfulness-based interventions may have a role to play in disease management. 

    Jedel et al. [Inflammatory Bowel Diseases] tested whether mindfulness-based stress reduction (MBSR) could reduce symptom flare frequency and severity in patients with inactive ulcerative colitis.

    The researchers randomly assigned 43 meditation-naïve ulcerative colitis patients with inactive disease (average age = 42 years; 58% female; 72% Caucasian) to either modified MBSR or a psychoeducational control. MBSR was delivered in 8 weekly 1½-2-hour weekly group sessions with a 4-hour retreat in the 7th week. The shortened session lengths were made to accommodate the very small class sizes.

    The psychoeducational control consisted of similarly structured group sessions with didactic material on the causes of physical illness, the effects of stress on physical health, the protective role of exercise, and cardiovascular disease risk factors. 

    Participants completed assessments at baseline, post-intervention, and 6- and 12-month follow-up. Participants completed measures of perceived stress, depression, anxiety, sleep quality, mindfulness (Five-Facet Mindfulness Questionnaire), disease symptoms and quality of life. They also submitted stool, urine, and blood samples, and were given sigmoidoscopies. 

    Stool samples were evaluated for levels of calprotectin which is associated with bowel inflammation, and urine samples were evaluated for levels of cortisol (a stress hormone). Blood samples were assessed for the proinflammatory biomarkers IL-6, IL-8, and C-reactive protein.

    The results showed MBSR participants experienced significantly fewer flares: none of the 20 MBSR participants experienced flares while 5 of the 23 controls did. There were no significant between-group differences on any biological or psychological measure once participants who experienced flares were excluded. Those who experienced flares were excluded because the steroid treatment they received for their flares would have influenced their biological markers.

    Mindfulness scores were significantly correlated with decreased perceived stress scores (r= -.54) and calprotectin levels were correlated with elevated urinary cortisol (r = .37), supporting the role of stress in ulcerative colitis.

    The study shows that MBSR reduced the incidence of symptom flares in ulcerative colitis patients relative to a psychoeducation program.

    The study is limited by its small sample size. The researchers also interpreted MBSR as having a positive effect on several psychological variables (e.g., mindfulness, depression) because of significant within-group improvements on these variables over time even though there were no between-group differences on these variables.


    Jedel, S., Beck, T., Swanson, G., Hood, M. M., Voigt, R. M., Gorenz, A., Jakate, S., Raeisi, S., Hobfoll, S., & Keshavarzian, A. (2022). Mindfulness Intervention Decreases Frequency and Severity of Flares in Inactive Ulcerative Colitis Patients: Results of a Phase II, Randomized, Placebo-Controlled Trial. Inflammatory Bowel Diseases.

    Link to study

  • 29 Jun 2022 9:10 AM | Anonymous member (Administrator)

    To err is human, but for organizations like hospitals even small errors can cost lives. Organizations try to anticipate and avoid errors, and high-stake demands to not err can motivate employees to hide mistakes when they occur. People who are more “authentic” may be less likely to hide their errors because their self-worth is less dependent on what others think of them.

    Mindfulness may aid authenticity by facilitating greater self-awareness and self-acceptance, thereby enabling people to act in accord with their values. 

    Choi et al. [Journal of Occupational Health Psychology] explored how changes in mindfulness affect authenticity and error hiding. They also studied the effects of mindfulness training compared to exercise or a wait-list control on mindfulness, authenticity, error hiding, and qualitative interview content.

    The researchers randomly assigned 230 employees (94% female; age range=25-54 years; 35% held front-line clinical roles) from four Canadian hospitals to Mindfulness-Based Stress Reduction (MBSR), Pilates training, or a wait-list control.

    The 8-week MBSR program was modified so that weekly group-based classes were one hour long. Pilates exercise training was also taught in a series of 8 one-hour weekly group sessions and was designed to improve core strength, balance, flexibility, and relaxation. 

    Participants were assessed at baseline, post-intervention, and one-month follow-up on measures of mindfulness (5 items from the Mindful Attention and Awareness Scale), authentic functioning (12 items from the Authentic Functioning Scale) and error hiding (3 items from the Error Orientation and Motivation Scale).

    The authentic functioning measure included items like “I frequently pretend to enjoy something when in actuality I really don’t.” The error hiding measure included items like “I do what I can to make sure that no one knows I make mistakes.”

    The results show that all three groups showed increases in mindfulness scores over time but there were no significant between-group differences. The MBSR group showed significantly greater increases in authentic functioning than both comparison  groups at post-intervention and follow-up. There were no significant differences in error hiding over time or between conditions.

    The researchers then examined the interrelationship between changes in variables over time regardless of group assignment. They found that the rate of increase in mindfulness correlated with the rate of increase in authentic functioning (r = .76), which in turn correlated with the rate of decrease in error hiding (r = -.45). 

    A qualitative analysis of post-intervention interviews with MBSR and Pilates participants showed increases in self-acceptance, self-awareness, self-compassion, self-esteem, and self-determination. There were dramatic between-group differences in how often these themes were reported. For example, 71% of the MBSR group reported improvements in attention and awareness, while only 21% of the Pilates exercise group did.

    Similarly 50% of the MBSR group reported greater life fulfillment, while 0% of the Pilates group did. The same magnitude of differences occurred with greater reports of improved work-related outcomes, interpersonal effects, emotional regulation, and relationship with oneself in the MBSR group.

    The study shows MBSR is more effective in increasing authentic functioning than Pilates exercise or a wait-list control. There was no evidence MBSR reduces error hiding, but the error hiding measure used was probably too brief to show much variability in scores. It also only measured what people were willing to say about how they viewed making errors, and did not measure actual errors, either hidden or unhidden.

    The study is limited by its reliance on self-report measures, and the fact that qualitative analysis raters were not blinded to condition.


    Choi, E., Leroy, H., Johnson, A., & Nguyen, H. (2022). Flaws and all: How mindfulness reduces error hiding by enhancing authentic functioning. Journal of Occupational Health Psychology.

    Link to study

  • 27 Jun 2022 11:55 AM | Anonymous member (Administrator)

    Findings from several pilot studies have led many to believe that just 8 weeks of Mindfulness-Based Stress Reduction (MBSR) can induce measurable brain structural changes. These changes, if true, would be important to highlight the mechanisms underlying gains in attention and emotion regulation after individuals participate in MBSR.

    MBSR studies that show structural brain changes, however, rely on small participant samples and either use participants as their own controls or lack active controls. Such preliminary study designs tend to err on the side of detecting effects that are not always genuine or robust.  

    Kral et al. [Science Advances] attempted to replicate the previous findings that showed brain structural changes occurring after MBSR. The investigators pooled Magnetic Resonance Imaging (MRI) data from two previously published studies that had sufficient sample sizes and used randomization to groups as well as an active control comparison condition. Pooling data from two studies can increase  power to detect significant brain change differences by study group.

    The researchers pooled then analyzed data from two published studies (N=218, average age = 46; 61% female; 84% Caucasian). Participants were drawn from a non-patient population and were meditation naïve. They were randomly assigned to a standard 8-week MBSR program, a Health Education Program, or a wait-list control. MBSR and Health Education

    Programs were matched on the number and length of group classes and the amount of homework assigned. The Health Education Program included exercise, music therapy, and nutrition education and practice. 

    Participants were assessed at baseline and post-intervention on a variety of psychological measures including the Five Facet Mindfulness Questionnaire, and on MRI scans that yielded brain structural measures of gray matter density, gray matter volume, and cortical thickness. Brain regions of interest included the amygdala, hippocampus, cerebellum, posterior parietal cortex, temporal-parietal junction, caudate, and insula.

    The pooled results showed no significant between-group differences on any brain structural changes in the areas of interest. The only significant result was an association between the amount of MBSR home practice and reduced right amygdala volume (partial η2=0.08), but there was no significant group x home practice time interaction.

    While brain structure remained unchanged, previously published data from these studies showed significant between-group differences in mindfulness, psychological well-being, and brain region functional connectivity.

    This replication analysis of pooled data from two controlled trials does not support results from previous studies showing that 8-weeks of MBSR induces structural brain changes. The study does not rule out the possibility that longer amounts of mindfulness practice, beyond eight weeks, may induce structural brain changes.

    The study is important in that it underscores the importance of conducting well-controlled replication studies before pilot study results can be interpreted with confidence. 


    Kral, T. R. A., Davis, K., Korponay, C., Hirshberg, M. J., Hoel, R., Tello, L. Y., Goldman, R. I., Rosenkranz, M. A., Lutz, A., & Davidson, R. J. (2022). Absence of structural brain changes from mindfulness-based stress reduction: Two combined randomized controlled trials. Science Advances

    Link to study

  • 2 Jun 2022 9:05 AM | Anonymous member (Administrator)


    Epigenetics is the study of how behaviors and environments turn the genes of our fixed DNA “on” or “off” to  produce proteins and so alter cellular activity. NF-κB (Nuclear Factor kappa B) refers to a family of naturally occurring protein transcription factors that activate DNA to regulate our immune cells.

    In response to stress in humans and other animals, there is often increased NF-κB activity that functions as an evolved inflammatory response to address the physical injury often accompanying stress. 

    Prior research shows that mindfulness training can down-regulate pro-inflammatory gene expression in samples experiencing elevated stress including lonely older adults, breast cancer survivors, and people with sleep disorders.

    Dutcher et al. [Brain, Behavior, and Immunity] conducted a randomized controlled trial to test whether mindfulness training down-regulates pro-inflammatory gene expression in elevated stress adults who lack pre-existing medical conditions.

    The researchers randomly assigned 100 generally healthy call-center customer service employees (average age= 34 years; 67% female; 64% Caucasian) who reported elevated subjective levels of stress to a mindfulness training or active control condition.

    Participants listened to 10-20-minute daily audio lessons on their smartphones across 30 days. Compliance was high, with each groups completing 97% of their smartphone assignments.

    The mindfulness group listened to audio content of the Headspace app basics program that offers guided mindful awareness practices. The control group listened to audio content for a similar amount of time that focused on problem solving, planning, analytic thinking, self-reflection, and guided imagery. This comparator was intended to also reduce levels of perceived stress.

    Participants completed a perceived stress scale and donated blood samples at baseline and one-week post-intervention. RNA was extracted from blood samples and analyzed for gene expression patterns.

    The results showed both the mindfulness group (d = 0.87) and the active control group (d = 0.86) showed significant large-sized reductions in subjectively reported stress. There was no significant between-group difference.

    The mindfulness group showed a greater reduction in gene activation in the pro-inflammatory NF-κB pathway than did controls (d = -0.30). The effect size for the difference in gene activation between groups was small. 

    This human subjects trial showed both mindfulness training and psychoeducation apps reduce subjectively reported stress levels in people who are generally healthy and employed yet with elevated stress. Only the mindfulness group showed a significant reduction in pro-inflammatory gene expression activity. This finding is potentially important because elevated inflammation is associated with a variety of physical and mental illnesses.

    The study is limited by its lack of long-term follow-up as well as a lack of a waitlist control to account for extraneous factors influencing genomic activity.


    Dutcher, J. M., Cole, S. W., Williams, A. C., & Creswell, J. D. (2022). Smartphone mindfulness meditation training reduces Pro-inflammatory gene expression in stressed adults: A randomized controlled trial. Brain, Behavior, and Immunity, 103, 171–177. 

    Link to study

  • 1 Jun 2022 10:43 AM | Anonymous member (Administrator)

    Smartphone apps are handy for collecting data as well as for delivering intervention content. This opens the possibility of collecting objective data from large samples of participants without tying up limited research laboratory time and budgets.  

    Axelsen et al. [BMC Psychology] tested the effect of smartphone app-based mindfulness training against app-based music listening on attention and cognitive working memory in a large sample of business employees. A novelty of this study was the use of smartphone-based cognitive games to assess changes in participant attention and working memory.

    The researchers used social media ads to recruit 623 Danish business employees to participate in a stress-reduction study. Participants were randomly assigned to a mindfulness, music-listening, or wait-list control condition. After excluding drop-outs and participants with incomplete data, data were analyzed from a sample of 459 participants (average age = 39 years; 50% male).

    Drop-out and noncompletion rates were similar for the mindfulness (32%) and music (29%) groups, and lower for the wait-list controls (14%). 

    The mindfulness group listened to audio lessons on the Headspace apps basics program for 10 minutes daily for 30 days. The music group listened to music selections from four playlists (“focus,” “binaural beats,” “piano, “Low-Fi”) for 10 minutes daily for 30 days.

    Prior studies show that music listening can improve sustained attention and reduce mental fatigue, while listening to binaural beats in the beta wave range can improve mood and vigilance. 

    Participants completed baseline and post-intervention measures using a perceived stress scale and two smartphone games related to cognitive performance. The “Go Sushi Go” game served as a measure sustained attention, that is, the ability to maintain focus on a task over time. Whenever participants saw an image of fresh sushi, they were to tap the screen, and whenever they saw a piece of spoiled sushi, they were to do nothing. 

    The “Animal Parade” game served as a measure of working memory, that is, holding previously observed information in mind and then recalling that information. As images of animals floated by one at a time, participants tapped the screen whenever an image was the exact same they saw two animals before that image. Participants earned points for correct answers that they could then use to access new “worlds” within the app.

    Results showed both the mindfulness (d = 0.67) and the music (d = 0.60) groups experienced decreased perceived stress, while the control group did not (η2p = 0.05). The mindfulness (d = -0.8) and music (d = -0.3) groups showed improved sustained attention scores on the “Go Sushi Go” game but the control group did not (η2p = 0.07); score improvement in the mindfulness group was significantly greater than that of the music and control groups.

    Only the mindfulness group (d = 0.95) showed improved working memory scores on “Animal Parade” game (η2p=0.17).

    The study shows that mindfulness training or music app use for 10 minutes daily reduces aggregate group levels of perceived stress relative to a waitlist control. The mindfulness app also improves performance scores related to sustained attention and working memory better than an active music-listening control.

    The study demonstrates the potential of using smartphones to deliver interventions as well as to assess outcomes, allowing researchers to obtain adequate sample sizes with less inconvenience to participants and researchers. 


    Axelsen, J. L., Meline, J. S. J., Staiano, W., & Kirk, U. (2022). Mindfulness and music interventions in the workplace: Assessment of sustained attention and working memory using a crowdsourcing approach. BMC Psychology, 10(1), 108. 

    Link to study

  • 26 Apr 2022 3:14 PM | Anonymous member (Administrator)

    We often comfort those who are distraught by offering them the same advice we would offer ourselves were we in the same situation. Helping others to emotionally self-regulate can sometimes be stressful, however, especially when one’s efforts fail. Mindfulness-Based Stress Reduction (MBSR) can help people regulate their own stress but little is known about whether it can also reduce the stress of trying to help others. 

    Guendelman et al. [Neuroimgage] used a randomized controlled trial to test the effect of MBSR on participants’ use of acceptance, permission, and cognitive reappraisal strategies to regulate their own stress as well as the stress of another person and examined the brain regions associated with self- and other-regulation.

    The researchers randomly assigned 68 German adults (average age = 38 years; 83% female) to either MBSR or a control condition. The MBSR program met in 8 standard weekly 2.5-hour group sessions with an all-day retreat and homework.

    The control group met with the same frequency and read, listened to, shared, and discussed works of fiction, myth, and poetry in group and listened to audiobooks at home. 

    Participants were assessed at baseline and after intervention on a self-other emotional regulation task while undergoing brain functional magnetic resonance imaging (fMRI). The task required participants to alternately try to regulate their own emotions and the emotions of a confederate as they both viewed aversive and neutral photographs.

    The photographs included the instructions “Gently accept!”, “Permit the reaction!”, or “This is just a photo!” which the participants alternately voiced to either themselves or the confederate. Participants were instructed as to what these acceptance, permission, and reappraisal strategies involved before beginning the task. These strategies were designed to reflect the strategies often presumed to underlie the effectiveness of MBSR.

    Participants were also given false feedback on some trials that they had failed to successfully regulate their own or the confederate’s stress. Participants rated their stress after each photograph.

    Study results showed the MBSR group showed significantly lower stress over time during self-regulation reappraisal trials while controls did not (η2p= .11). During self-regulation acceptance trials, the control group experienced increasing levels of stress, while the MBSR group did not (η2p= .09). No significant group x time interactions were found during the other-regulation trials or during any of the “permission” trials. 

    A complex pattern of significant brain region activation differences were found between the MBSR and control group during self-regulation acceptance, other-regulation reappraisal, and other-regulation acceptance trials.

    The group of MBSR participants displayed greater brain activation in the parietal and insular cortices when regulating self-stress and in the precuneus and temporo-parietal junction when regulating other’s stress, especially while using the acceptance strategy. Brain region activation levels were not correlated with changes in self-reported stress.

    The study shows MBSR can help participants self-regulate their own stress through both acceptance and cognitive reappraisal strategies but has no effect on the stress of attempting to regulate another person’s emotions.

    Interpretation of the study is complicated by the fact that MBSR participants reported significantly greater stress during self-regulation reappraisal trials at baseline. 


    Guendelman, S., Bayer, M., Prehn, K., & Dziobek, I. (2022). Towards a mechanistic understanding of mindfulness-based stress reduction (MBSR) using an RCT neuroimaging approach: Effects on regulating own stress in social and non-social situations. NeuroImage, 119059. 

    Link to study

  • 25 Apr 2022 11:16 AM | Anonymous member (Administrator)

    Infants whose mothers were highly stressed during pregnancy often show altered autonomic nervous system responsiveness to stress after birth. This is important because autonomic responsiveness is associated with childhood behavioral problems. For example, dysregulated  sympathetic reactivity is associated with antisocial behavior, substance use, and anxiety. Mindfulness-based interventions that reduce maternal stress may potentially exert influence on fetal development.

    Noroña-Zhou et al. [Psychosomatic Medicine] compared autonomic and behavioral reactivity and regulation in infants whose mothers with elevated stress had previously participated in either a mindfulness-based program or a control group during pregnancy.

    The researchers identified 135 6-month-old infants (46% Mixed Race, 36% Black, 17% White) whose mothers had previously completed an 8-week Mindful Moms Training intervention during pregnancy or had served as controls for that study. The mothers were primarily low-income (median income = $18,000) who reported high levels of stress. 

    The Mindful Moms program was delivered in eight 2-hour weekly group sessions that combined Mindfulness-Based Stress Reduction, mindful-eating, and support for nutrition and exercise. The control condition was maternity care provided as usual. Previously published results from this trial showed Mindful Moms improved mothers’ levels of stress, depression, activity level, and glucose tolerance relative to controls. 

    Sixty-five of the infant-mother pairs were assessed at 6 months of age using a five phase “still face” paradigm to induce infant stress. In this, mothers played normally with their infants for 30 seconds, then stopped interacting with or responding to them and maintained a neutral facial expression for another 30 seconds. The parents then resumed normal responsiveness followed by another “still face” episode and a final resumption of normal responsiveness. 

    Infant electrocardiograms (EKGs) were monitored throughout the task. EKG respiratory sinus arrythmias served as a measure of parasympathetic reactivity and the length of EKG pre-ejection periods served as a measure of sympathetic reactivity. Infant behaviors were videotaped and rated by study blinded observers for fussing, withdrawal, and protest as well as visual engagement with objects in the environment.

    Results showed infants in the Mindful Moms group increased their sympathetic activity earlier on in the first still face episode than controls, but that controls showed persistent elevated sympathetic activity throughout the remainder of the task whereas mindful infants returned towards baseline.

    While all infants showed some decline in positive visual engagement with objects after the first still face episode, mindful infants declined less and showed greater positive visual engagement than controls during the remainder of the task.

    There were no group differences in parasympathetic activity or negative behaviors like fussing or withdrawal.

    The findings of the study reveal that infants of stressed mothers who participated in a mindfulness intervention show increased sympathetic responsiveness, better sympathetic recovery, and more persistent visual engagement with the environment in response to stress than controls.

    The study is limited by its lack of baseline equivalence for gestational age yet this variable was not influential on the treatment effect when covaried statistically. 


    Noroña-Zhou, A. N., Coccia, M., Epel, E., Vieten, C., Adler, N. E., Laraia, B., Jones-Mason, K., Alkon, A., & Bush, N. R. (2022). The Effects of a Prenatal Mindfulness Intervention on Infant Autonomic and Behavioral Reactivity and Regulation. Psychosomatic Medicine.

    Link to study

  • 4 Apr 2022 9:13 AM | Anonymous member (Administrator)

    Elevations and large fluctuations in eye fluid pressure are risk factors for glaucoma, a disease that results in optic nerve damage and blindness. Experts disagree on when it is best to monitor eye fluid pressure and when it is best to initiate medical treatment.

    While pharmacological treatments reduce glaucoma risk, they can be expensive and cause unwanted side effects. In addition, knowing one is at risk for glaucoma can increase stress which can further elevate eye fluid pressure and decrease quality of life. 

    Dada et al. [American Journal of Ophthalmology] investigated whether mindfulness meditation could reduce eye fluid pressure and fluid pressure fluctuations, thus delaying or reducing the need for pharmaceutical treatment. Normal eye fluid pressure is ≤ 20 mm Hg, and every 1 mm Hg decrease in pressure results in a 10% decrease in glaucoma risk.

    The researchers randomly assigned 60 patients attending a New Delhi glaucoma clinic with eye fluid pressure elevations of 21-30 mm Hg (average age = 52 years) to mindfulness meditation or a wait-list control group. The mindfulness group included two one-hour trainings in breath-focused mindfulness meditation and 60-minutes  of daily practice  at home for 6 weeks.

    Study personnel called participants on a weekly basis to encourage continued practice and insure correct technique. Participants completed assessments at baseline and six weeks after baseline (or after intervention) on measures of eye fluid pressure (taken every 3 hours across  a 15-hour interval), optic disc blood vessel density and perfusion, a single 8:00 AM blood serum cortisol, and self-reported quality-of-life.

    The results showed the mindfulness group had a significantly greater reduction in eye fluid pressure (-3.9 mm Hg) than controls (-0.18 mm Hg). The mindfulness group also showed significant reductions in diurnal pressure fluctuation (-2.14 mm Hg) while controls did not (-0.20 mm Hg).

    Average optic disc blood vessel density and perfusion improved more for mindfulness than control participants. The mindfulness group also reported a significantly greater improvement in quality of life than controls.

    Lastly, mindfulness practitioners saw a significantly greater decrease in morning serum cortisol (-2.54 μg/dl) than controls (+0.38 μg/dl). Serum cortisol reductions were correlated with decreased eye fluid pressure (r=-.73), reduced diurnal fluctuation in pressure (r=-.56), and improved quality of life (r=.62).

    The study shows mindfulness mediation training can reduce clinically-evaluated risk factors for developing glaucoma. The reported average drop in eye fluid pressure for mindfulness participants reflects a 39% decrease in risk for glaucoma progression.

    It is unclear how long this improvement persists, and how much daily meditation practice is needed to maintain it. The study is limited by its lack of published information on the extent of home practice compliance and the absence of an active control.


    Dada, T., Mondal, S., Midha, N., Mahalingam, K., Sihota, R., Gupta, S., Angmo, D., & Yadav, R. K. (2022). Effect of mindfulness-based stress reduction on IOP in patients with ocular hypertension: A randomized control trial. American Journal of Ophthalmology. 

    Link to study

  • 17 Mar 2022 8:56 AM | Anonymous member (Administrator)


    Mindfulness-based trainings typically combine focused-attention meditation with open-monitoring meditation that involves attending to the entire field of awareness. Little is known about how these different types of meditation uniquely contribute to emotional well-being.

    Brown at al. [Psychophysiology]
    investigated the effects of these meditations, separately and combined, on measures of emotional reactivity and regulation. 

    The researchers randomly assigned 104 meditation-naïve predominantly female, Caucasian adults (average age = 40 years) with persistent mild-to-severe depression, anxiety, and/or stress to a focused-attention meditation training program, an open-monitoring meditation program, or a Mindfulness-Based Cognitive Therapy (MBCT) program that includes both types of meditation training. 

    All three programs were offered in formats that included 8 three-hour weekly groups and a full-day retreat. Participants were encouraged to engage in 45 minutes of daily home meditation practice. The focused-attention group used sensations such as the breath to anchor their meditations, while the open-monitoring group used mental noting to attend to the full range of sensory, cognitive, and emotional experiences.

    Participants completed baseline and post-training electroencephalographic (EEG) measures of emotional reactivity and regulation. They were presented with a series of computerized positive, negative, and neutral images.

    For the first 4 seconds of each image presentation, participants simply looked at the image allowing emotional reactions to arise. During the following 10 seconds they employed the meditative strategy they had been taught to regulate their emotional reactions to the picture—either breathing or mental noting. Participants also rated their mood after each viewing. 

    An EEG recorded any frontal lobe alpha wave asymmetry in response to the images. Greater left > right frontal alpha wave activity is associated with an approach response to stimuli, while greater right > left frontal alpha wave activity is associated with an avoidance response.  Increased left > right activity reflects a decrease in negative emotional responsiveness to a stimulus.

    Over the course of training, the MBCT and focused-attention groups showed significantly greater increased leftward shifts in alpha wave asymmetry compared to the open-monitoring group. This was true for both the emotional reactivity and the emotional regulation phases of EEG recording. 

    All three groups reported improved self-reported mood while viewing negative images from baseline to post-training with open-monitoring (d=0.63) and focused-attention groups (d=0.54) showing larger mood improvements than the MBCT group (d=0.21). 

    The study shows greater shifts in frontal lobe alpha wave asymmetry for focused-attention and MBCT training, but greater improvement in self-reported mood for open-monitoring training. It is not clear why these EEG and self-report results diverge. The study is limited by the lack of a non-meditation control group.


    Brown, K. W., Berry, D., Eichel, K., Beloborodova, P., Rahrig, H., Britton, W. B. (2022). Comparing impacts of meditation training in focused attention, open monitoring, and mindfulness-based cognitive therapy on emotion reactivity and regulation: Neural and subjective evidence from a dismantling study. Psychophysiology.

    Link to study

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